Comparing the Efficacy of Topical Terbinafine 1%Cream with Topical Ketoconazole 2%Cream and Placebo in the Treatment of Facial Seborrhoeic Dermatitis
HamidehHerizchi, Shahla Babaie Nejad, Sara Saniee
Abstract
Background and Objectives: Previous uncontrolled trials have suggested that topical terbinafine 1% cream could be useful in the treatment of seborrhoeic dermatitis. The aim of the present study was to evaluate the clinical efficacy of topical terbinafine 1% cream in patients with facial seborrhoeic dermatitis.
Materials and Methods: Ninety outpatients with seborrheic dermatitis were randomized into three groups: topical terbinafine 1% cream (n=30), topical ketoconazole 2% cream (n=30), and placebo (n=30). The patients received one of these treatments twice daily for 4 weeks. Clinical evaluation of erythema, scaling and itching, each scored on a 0-3 scale was recorded at weeks 0, 4, and 12.
Results: At baseline, the mean total clinical score was 5.04±2.02, 5.04±1.50 and 4.97±1.71 in the terbinafine, ketoconazole and placebo groups, respectively. At week 12, the mean total clinical score was 1.78±2.47, 1.81±2.43 and 3.73±1.74 in the terbinafine, ketoconazole and placebo groups, respectively. A significant decrease in the mean total clinical score was found in the terbinafine and ketoconazole groups compared with the placebo group (P=0.003), while response to terbinafine was not significantly different from that to the ketoconazole (P>0.05).
Conclusion: Terbinafine 1% cream had a comparable efficacy and safety profile to that of ketoconazole 2% cream in the treatment of facial seborrheic dermatitis.
Keywords: Facial seborrhoeic dermatitis, Terbinafine, Ketoconazole
Pulmonary Langerhans cell histiocytosis with Skin involvement; an amazing case report Sara Saniee, Niloofar Afshari, Saeed Kashefi Abstract Introduction: Langerhans cell histiocytosis (LCH) is a
Necrolytic Migratory Erythema Associated With Glucagonoma Syndrome Sara Saniee, Yalda Saniee, Armaghan G Zare, Ghazaleh Davarnia Abstract Necrolytic migratory erythema (NME) is a rare cutaneous
Expression of cyclooxygenase-2 in melanocytic skin lesions by immunohistochemistry Armaghan Ghareaghaji Zare, Effat Khodayiani , Sara Saniee, Shahla Talghini Abstract Introduction: cyclooxygenase-2 (COX-2) is involved
Coexistance of Pemphigus Vulgaris and Psoriasis in a Middle Aged Man Sara Saniee, Armaghan Ghareaghaji Zare Abstract Psoriasis and pemphigus vulgaris are two inflammatory and
Human immunodeficiency virus, hepatitis B virus, hepatitis C virus, and syphilis co-infections among patients with anogenital warts in Tabriz, Iran Sara Saniee , Hamideh Herizchi-Qadim1, Mohammadreza